Science

3 leading COVID experts say there isn’t clear evidence that healthy, vaccinated people will need booster shots 8 months out

Summary List PlacementThe federal government has officially recommended COVID-19 booster shots for all. In a statement on Wednesday, US health officials said all Americans who received an mRNA vaccine from Pfizer or Moderna may get a boost eight months after their second shot. A booster is not yet recommended for people who received a J&J vaccine, which uses different vaccine technology. "The current protection against severe disease, hospitalization, and death could diminish in the months ahead," the officials said, "especially among those who are at higher risk or were vaccinated during the earlier phases of the vaccination rollout." Experts in the field...

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Summary List Placement

The federal government has officially recommended COVID-19 booster shots for all.

In a statement on Wednesday, US health officials said all Americans who received an mRNA vaccine from Pfizer or Moderna may get a boost eight months after their second shot. A booster is not yet recommended for people who received a J&J vaccine, which uses different vaccine technology.

“The current protection against severe disease, hospitalization, and death could diminish in the months ahead,” the officials said, “especially among those who are at higher risk or were vaccinated during the earlier phases of the vaccination rollout.”

Experts in the field weren’t particularly surprised at the announcement. Everyone from the CDC to the FDA to pharmaceutical companies has anticipated that COVID-19 booster doses will eventually be necessary.

However, there is some debate about the new plan — including whether it is the right approach to contain the pandemic at this juncture, and who really needs boosters.

Immunologist John Moore from Weill Cornell Medical College said he trusts that the Biden administration’s recommendation is “science driven.” But like others interviewed for this story, he questioned how much boosting people who are already well protected from disease and death — i.e. fully vaccinated people under 60 who aren’t immunocompromised — will move the needle in the pandemic. 

“The unvaccinated are the drivers of this pandemic. If we didn’t have 100 million unvaccinated people, we wouldn’t be having this kind of conversation because the pandemic would have been squelched in America several months ago,” he said. 

Why US officials recommend boosters at 8 months

Rochelle Walensky

In announcing the new recommendations on Wednesday, the CDC shared a few data sets that influenced its decision.

CDC director Rochelle Walensky referenced data from Israel and New York, as well as a preprint from the Mayo Clinic, which all showed that protection from the vaccines wanes slightly over time. One study found that the Pfizer and Moderna mRNA vaccines were 75% effective at preventing infection in nursing homes in the spring, but by summer, with Delta spreading, they were 53% effective. Another study showed that the two vaccines protect very well against severe COVID-19 and hospitalization for up to six months. 

Pfizer’s own research, meanwhile, suggests that its vaccine is highly protective (91.3% efficacy) against symptomatic COVID-19 for six months after the second dose. On Monday, Pfizer submitted data to the FDA recommending boosters six to 12 months after the second dose. The people in their study received boosters eight to nine months out.

Taken together, these findings suggest vaccine effectiveness does wane over time, especially in the face of the Delta variant. But it’s still not clear when the optimal time is for a booster shot.

“There’s no question that a third dose does increase antibody response,” Moore said. “The debate has been whether and when it was necessary to do this.”

Walensky said the biggest factor driving the eight-month booster recommendation is to “stay ahead of the virus.” And vaccines have proven to be our best tool: The US-authorized shots, which were first rolled out eight months ago, have protected vaccinated Americans from symptomatic infection and severe illness and saved hundreds of thousands of lives.

 “You don’t want to find yourself behind, playing catch up,” Dr. Anthony Fauci said in a press conference on Wednesday.

Boosters seem to protect vaccinated people from mild illness

The Hamptons in summer

Studies have shown that COVID-19 booster doses increase the antibody levels in vaccinated people’s blood. Higher antibody levels in general are associated with greater immune protection.

Dr. Robert Atmar, who’s leading a booster trial at Baylor College of Medicine, said he suspects boosters could even prevent some cases of long COVID by protecting vaccinated people from mild illness.

“That’s always a good thing,” Atmar said, though he added: “It may be a little bit of extrapolation to suggest that a booster is warranted.” 

What is surely warranted right now, Atmar said, is curbing the soaring rate of hospitalizations among the 50% of Americans who remain unvaccinated or partially vaccinated. Boosters might not do much to address that. 

“Will it keep more people out of the hospital? Maybe, but I don’t know that,” he said, adding, “targeting the unvaccinated would have a greater effect, from a public health standpoint, if those individuals could be persuaded to accept the vaccine.”

Boosters do not solve the real problem: keeping unvaccinated people out of the hospital

louisiana covid hospital

Dr. Paul Offit, a pediatrician at the Children’s Hospital of Philadelphia and co-inventor of the rotavirus vaccine, said the goal of these boosters should be the same as any vaccination: to eliminate “the worst things the virus can do.”

Offit, like Moore and Atmar, believes that aim would be better achieved by first vaccinating more people who haven’t got their first dose, rather than bolstering protection for those who have.

“The real problem in this country is not that we need to boost the vaccinated, it’s that we need to vaccinate the unvaccinated,” Offit said. “That’s the problem. Until we do that, we’re going to suffer in this country.” 

Moore put it even more starkly: “There are 100,000 to 200,000 people walking around America today who will be dead by the end of the year. And mostly self-inflicted, by refusing vaccination,” he said. “That’s the bigger issue.”

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